parkinsons#
You can see the full contents of this project on GitHub.
<Project Name>#
<1-2 sentences describing the project>
Papers#
How the papers were obtained#
Typically with pubget.
We recommend invoking pubget with the --query_file option, and storing a copy of the query file in the project’s directory, or including a copy in the README.md.
<description>
Where the full papers are stored#
Typically on OSF.
Please also add a documents/datasets.json file containing the URL where the full pubget dataset can be downloaded, that looks like:
[ { "url": "https://osf.io/download/<...>/" } ]
<description>
Annotations#
File(s) being annotated:#
/projects/<project_name>/documents/<documents_file1_name>.jsonlcorresponding file in the pubget output:
<pubget_folder_name>/subset_allArticles_labelbuddyData/<documents_file1_name>.jsonl
/projects/<project_name>/documents/<documents_file2_name>.jsonlcorresponding file in the pubget output:
<pubget_folder_name>/subset_allArticles_labelbuddyData/<documents_file2_name>.jsonl
Annotation labels:#
<label1>: <description of label1><label2>: <description of label2>
Labels found in other projects as well:#
<label2>
Instructions for annotators#
<description>
Labels in this project#
_Discarded (47 docs)
Example annotations:
…structural MRI images obtained from subjects with Parkinson disease (PD), compared to age-matched controls.
## Results
No significant differences in volume were detected in the thalami between eighteen normal subjects and eighteen PD subjects groups. However significant (p < 0.03) shape differences were detected between the Left vs. Right thalami in PD, between the left thalami in PD and controls, and between the …
…d from subjects with Parkinson disease (PD), compared to age-matched controls.
## Results
No significant differences in volume were detected in the thalami between eighteen normal subjects and eighteen PD subjects groups. However significant (p < 0.03) shape differences were detected between the Left vs. Right thalami in PD, between the left thalami in PD and controls, and between the right thalami in PD and c…
…). In this study we evaluated the clinical efficacy of using putaminal atrophy in brain MRI to differentiate MSA and PD.
## Methods
We measured the putamen/caudate volume ratio on brain MRI in 24 patients with MSA and 21 patients with PD. Two clinicians who were blinded to the patients' diagnoses and to each other's assessments measured the volume ratio using a computer program.
## Results
The …
…ated the clinical efficacy of using putaminal atrophy in brain MRI to differentiate MSA and PD.
## Methods
We measured the putamen/caudate volume ratio on brain MRI in 24 patients with MSA and 21 patients with PD. Two clinicians who were blinded to the patients' diagnoses and to each other's assessments measured the volume ratio using a computer program.
## Results
The measured volume ratios of…
…icacy of using putaminal atrophy in brain MRI to differentiate MSA and PD.
## Methods
We measured the putamen/caudate volume ratio on brain MRI in 24 patients with MSA and 21 patients with PD. Two clinicians who were blinded to the patients' diagnoses and to each other's assessments measured the volume ratio using a computer program.
## Results
The measured volume ratios of the two investigators were highly correlated ( r =0.72…
…highly correlated ( r =0.72, p <0.0001). The volume ratio was significantly lower in MSA (1.29±0.28) than PD (1.91±0.29, p <0.0001). Setting an arbitrary cutoff ratio of 1.6 resulted in about 90% of patients with MSA falling into the group with a lower ratio, whereas more than 80% of patients with PD belonged to the other group.
## Conclusions
The present results demonstrate that putaminal atrophy…
… in MSA (1.29±0.28) than PD (1.91±0.29, p <0.0001). Setting an arbitrary cutoff ratio of 1.6 resulted in about 90% of patients with MSA falling into the group with a lower ratio, whereas more than 80% of patients with PD belonged to the other group.
## Conclusions
The present results demonstrate that putaminal atrophy in MSA as measured on brain MRI represents an effective tool for differentiating MSA …
…al alterations in the brains of individuals with mild-moderate PD we quantified neurochemical profiles of the pons, putamen and substantia nigra by 7 tesla (T) proton magnetic resonance spectroscopy. Thirteen individuals with idiopathic PD (Hoehn & Yahr stage 2) and 12 age- and gender-matched healthy volunteers participated in the study. γ-Aminobutyric acid (GABA) concentrations in the pons and putamen were significa…
…e quantified neurochemical profiles of the pons, putamen and substantia nigra by 7 tesla (T) proton magnetic resonance spectroscopy. Thirteen individuals with idiopathic PD (Hoehn & Yahr stage 2) and 12 age- and gender-matched healthy volunteers participated in the study. γ-Aminobutyric acid (GABA) concentrations in the pons and putamen were significantly higher in patients (N = 11, off medications) than controls (N = 11, p<0.001 for pons an…
…cally to determine if alterations in neurotransmitter levels similar to those observed in animal models of PD would be detectable in patients with mild-moderate PD.
## Methods
### Subjects
Thirteen individuals with mild–moderate PD (6 women and 7 men, 56±10 years old, mean±SD) and 12 age-matched healthy volunteers (7 women and 5 men, 54±8 years old) participated in the study after giving written informed c…
ParticipantsInfo (34 docs)
Example annotations:
van der Hoorn, Anouk and Renken, Remco J. and Leenders, Klaus L. and de Jong, Bauke M.
PLoS One, 2014
# Title
Parkinson-Related Changes of Activation in Visuomotor Brain Regions during Perceived Forw…
Welter, Marie-Laure and Schüpbach, Michael and Czernecki, Virginie and Karachi, Carine and Fernandez-Vidal, Sara and Golmard, Jean-Louis and Serra, Giulia and Navarro, Soledad and Welaratne, Arlette an…
Chung, Eun Joo and Kim, Eung Gyu and Bae, Jong Seok and Eun, Choong Ki and Lee, Kwang Sig and Oh, Minkyung and Kim, Sang Jin
J Mov Disord, 2009
# Title
Usefulness of Diffusion-Weighted MRI for Differ…
Quattrocchi, Carlo Cosimo and de Pandis, Maria Francesca and Piervincenzi, Claudia and Galli, Manuela and Melgari, Jean Marc and Salomone, Gaetano and Sale, Patrizio and Mallio, Carlo Augusto and Cardu…
Al-Hourani, Khalid and Frost, Chelsea and Mesfin, Addisu
Geriatr Orthop Surg Rehabil, 2015
# Title
Upper Cervical Epidural Abscess in a Patient With Parkinson Disease
# Keywords
upper cervical
oste…
Lin, Wei-Che and Chen, Pei-Chin and Huang, Yung-Cheng and Tsai, Nai-Wen and Chen, Hsiu-Ling and Wang, Hung-Chen and Lin, Tsu-Kung and Chou, Kun-Hsien and Chen, Meng-Hsiang and Chen, Yi-Wen and Lu, Chen…
Nagae, Lidia M. and Honce, Justin M. and Tanabe, Jody and Shelton, Erika and Sillau, Stefan H. and Berman, Brian D.
Front Neuroanat, 2016
# Title
Microstructural Changes within the Basal Ganglia Diff…
Lu, Yan-Ting and Chang, Wen-Neng and Chang, Chiung-Chih and Lu, Cheng-Hsien and Chen, Nai-Ching and Huang, Chi-Wei and Lin, Wei-Che and Chang, Ya-Ting
Parkinsons Dis, 2016
# Title
Insula Volume and S…
Makovac, Elena and Cercignani, Mara and Serra, Laura and Torso, Mario and Spanò, Barbara and Petrucci, Simona and Ricciardi, Lucia and Ginevrino, Monia and Caltagirone, Carlo and Bentivoglio, Anna Rita…
Rittman, Timothy and Rubinov, Mikail and Vértes, Petra E. and Patel, Ameera X. and Ginestet, Cedric E. and Ghosh, Boyd C.P. and Barker, Roger A. and Spillantini, Maria Grazia and Bullmore, Edward T. an…
ParticipantsGroupInfo (34 docs)
Example annotations:
… effects of optic flow on motor-related cerebral circuitry were explored with functional magnetic resonance imaging in healthy controls (HC) and patients with Parkinson’s disease (PD). Fifteen HC and 22 PD patients, of which 7 experienced freezing of gait (FOG), watched wide-field flow, interruptions by narrowing or deceleration and equivalent control conditions with static dots. Statistical parametric mapping …
…es, surgical procedure, and locations of stimulating contacts that might help us to define the best target for a given patient.
## METHODS
### Patients.
Between February 1996 and July 2009, 309 patients with PD underwent DBS-STN at the Pitié-Salpêtrière Hospital (Paris, France). Patients were deemed suitable for surgery according to the following criteria : (1) age younger than 70 years (mean age: 5…
…e usefulness of DWI by using the rADC for differential diagnosis between MSA-p and PD and investigated the correlation between the rADC value and clinical features of MSA-p and PD.
## Methods:
Twelve patients with PD and 10 with MSA-p were studied. The rADC value was determined in different brain regions, including the dorsal putamen (DP) and middle cerebellar peduncles (MCP).
## Results:
The rADC …
…st whether measurable stimulus-specific functional connectivity changes exist after Automatic Mechanical Peripheral Stimulation (AMPS) in patients with idiopathic Parkinson Disease.
## Methods
Eleven patients (6 women and 5 men) with idiopathic Parkinson Disease underwent brain fMRI immediately before and after sham or effective AMPS. Resting state Functional Connectivity (RSFC) was assessed using the see…
… in a patient with PD and to review upper cervical spine infection. We present the patient’s presentation, physical examination, imaging findings, and management as well a review of the literature. A 66-year-old male with PD presented to the emergency department (ED) following referral by a neurologist for a presumed C2 fracture. The preceding history was 1 week of severe neck pain requiring a magnetic resonance …
…s reflected in a priori approval by the Chang Gung Memorial Hospital human research committee. All participants or their guardians provided written informed consent before participation in the study. Thirty-four right-handed PD and PDD patients (13 men and 21 women, mean age: 62.18 ± 9.1 years) were prospectively enrolled in the Neurology Department of Kaohsiung Chang Gung Memorial Hospital. Patients were included if they had a definitive d…
…verage of the left and right sides was used for the healthy control values when making comparisons between PD patients and healthy controls.
## Results
### Subject characteristics
Healthy controls ( N = 20) and PD patients ( N = 21) were closely matched in age (61.1 ± 9.0 vs. 61.1 ± 7.7, p = 0.97 ) and gender (11M:9F vs. 12M:9F, p = 0.89). Patient demographics broken down by motor subtype …
…sides was used for the healthy control values when making comparisons between PD patients and healthy controls.
## Results
### Subject characteristics
Healthy controls ( N = 20) and PD patients ( N = 21) were closely matched in age (61.1 ± 9.0 vs. 61.1 ± 7.7, p = 0.97 ) and gender (11M:9F vs. 12M:9F, p = 0.89). Patient demographics broken down by motor subtype are shown in Table . Disease…
…estigated structural brain change in subjects with a clinical diagnosis of Parkinson disease with mild cognitive impairment (PD-MCI) and examined its relationship with memory impairment. Methods. Twenty-three PD-MCI patients were enrolled and underwent cognitive evaluation and 3-dimensional T1-weighted imaging. Voxel-based morphometry (VBM) was used to assess brain-behavior correlations and examine the relationship betwe…
…duals. Conversely, in HET individuals, we expected to identify preclinical FC modifications in the absence of obvious neuropsychological deficits.
## Materials and Methods
### Participants
Eight HOM patients (5 PINK1 and 3 Park2 mutation carriers; M/F = 6/3; mean age = 51.4, SD = 8.1 years), 12 HET relatives (10 PINK1 and 2 Park2 mutation carriers; M/F = 5/10; mean age = 40.2, SD = 14.7 y…
_Mention (17 docs)
Example annotations:
…rmine the causes of variable outcome from deep brain stimulation of the subthalamic nucleus (DBS-STN) in patients with Parkinson disease (PD).
## Methods:
Data were obtained from our cohort of 309 patients with PD who underwent DBS-STN between 1996 and 2009. We examined the relationship between the 1-year motor, cognitive, and psychiatric outcomes and (1) preoperative PD clinical features, (2) MRI meas…
…tly, we measured the correlation between clinical characteristics and rADC values in patients with both PD and MSA-p.
## Subjects and Methods
### Patients
Twenty-two patients, comprised of 12 patients with PD and 10 patients with MSA-p, and 10 age-matched healthy controls participated in this study. Diagnosis of PD and MSA-p was performed by an experienced movement disorder specialist using establ…
…rimental protocol of the pilot interventional study as approved by the local ethical committee.
### Patients and clinical assessment
From September 15th to October 30th 2013, we investigated 11 patients (6 women and 5 men) with a diagnosis of PD according to the clinical diagnostic criteria of the United Kingdom Parkinson’s disease Society Brain Bank. Inclusion criteria were: 1) age of 45 years or o…
…ocol of the pilot interventional study as approved by the local ethical committee.
### Patients and clinical assessment
From September 15th to October 30th 2013, we investigated 11 patients (6 women and 5 men) with a diagnosis of PD according to the clinical diagnostic criteria of the United Kingdom Parkinson’s disease Society Brain Bank. Inclusion criteria were: 1) age of 45 years or older; 2) …
…pilot interventional study as approved by the local ethical committee.
### Patients and clinical assessment
From September 15th to October 30th 2013, we investigated 11 patients (6 women and 5 men) with a diagnosis of PD according to the clinical diagnostic criteria of the United Kingdom Parkinson’s disease Society Brain Bank. Inclusion criteria were: 1) age of 45 years or older; 2) a Hoehn & …
…inical scores before an after sham or effective AMPS were tested with the Wilcoxon-signed rank test for paired data by means of the SPSS software package 19.0.
## Results
### Patients
The 11 patients enrolled in the study were randomly assigned to a sham or effective AMPS according to the cross-over design ( ). Patients showed a clinical akinesia/rigidity subtype in 72% (8/11) while a tremor subt…
…modifications in any of the clinical measures. ( )
Demographic and clinical parameters of patients with Parkinson’s disease before and after effective AMPS and sham stimulation.
Among the 11 patients, 7 (4 female, 3 men) were included for fMRI analyses of resting state functional connectivity. The exclusion of four participants was necessary because of the following reasons: one patient showed a …
… any of the clinical measures. ( )
Demographic and clinical parameters of patients with Parkinson’s disease before and after effective AMPS and sham stimulation.
Among the 11 patients, 7 (4 female, 3 men) were included for fMRI analyses of resting state functional connectivity. The exclusion of four participants was necessary because of the following reasons: one patient showed a large arachno…
…e clinical measures. ( )
Demographic and clinical parameters of patients with Parkinson’s disease before and after effective AMPS and sham stimulation.
Among the 11 patients, 7 (4 female, 3 men) were included for fMRI analyses of resting state functional connectivity. The exclusion of four participants was necessary because of the following reasons: one patient showed a large arachnoid cyst…
…ability/gait difficulty (PIGD) subtypes. Fractional anisotropy, mean diffusivity, radial, and axial diffusivity were obtained from bilateral caudate, putamen, globus pallidus, and substantia nigra of 21 PD patients (12 TD and 9 PIGD) and 20 age-matched healthy controls. T -tests and ANOVA methods were used to compare PD patients, subtypes, and controls, and Spearman correlations tested for relationships betw…
ParticipantsSubGroup (3 docs)
Example annotations:
…able stimulus-specific functional connectivity changes exist after Automatic Mechanical Peripheral Stimulation (AMPS) in patients with idiopathic Parkinson Disease.
## Methods
Eleven patients (6 women and 5 men) with idiopathic Parkinson Disease underwent brain fMRI immediately before and after sham or effective AMPS. Resting state Functional Connectivity (RSFC) was assessed using the seed-ROI bas…
…s-specific functional connectivity changes exist after Automatic Mechanical Peripheral Stimulation (AMPS) in patients with idiopathic Parkinson Disease.
## Methods
Eleven patients (6 women and 5 men) with idiopathic Parkinson Disease underwent brain fMRI immediately before and after sham or effective AMPS. Resting state Functional Connectivity (RSFC) was assessed using the seed-ROI based analysi…
…Gung Memorial Hospital human research committee. All participants or their guardians provided written informed consent before participation in the study. Thirty-four right-handed PD and PDD patients (13 men and 21 women, mean age: 62.18 ± 9.1 years) were prospectively enrolled in the Neurology Department of Kaohsiung Chang Gung Memorial Hospital. Patients were included if they had a definitive diagnosis…
…al Hospital human research committee. All participants or their guardians provided written informed consent before participation in the study. Thirty-four right-handed PD and PDD patients (13 men and 21 women, mean age: 62.18 ± 9.1 years) were prospectively enrolled in the Neurology Department of Kaohsiung Chang Gung Memorial Hospital. Patients were included if they had a definitive diagnosis of idiopathi…
…issue characteristics at the preexcited segment in adult WPW syndrome patients and their implicated findings.
## Methods
For this prospective study, we enrolled 22 adult WPW syndrome patients (16 male, mean 45.4 ± 17.8 years) with echocardiographic findings of regional wall motion abnormality in our electrophysiology clinic. Of these patients, 14 underwent radiofrequency ablation before cardiac ma…
AgeMoments (3 docs)
Example annotations:
…search committee. All participants or their guardians provided written informed consent before participation in the study. Thirty-four right-handed PD and PDD patients (13 men and 21 women, mean age: 62.18 ± 9.1 years) were prospectively enrolled in the Neurology Department of Kaohsiung Chang Gung Memorial Hospital. Patients were included if they had a definitive diagnosis of idiopathic PD and had been foll…
…ns in the absence of obvious neuropsychological deficits.
## Materials and Methods
### Participants
Eight HOM patients (5 PINK1 and 3 Park2 mutation carriers; M/F = 6/3; mean age = 51.4, SD = 8.1 years), 12 HET relatives (10 PINK1 and 2 Park2 mutation carriers; M/F = 5/10; mean age = 40.2, SD = 14.7 years) and 22 age- and gender-matched healthy controls (HC; M/F = 10/12; mea…
….1 years), 12 HET relatives (10 PINK1 and 2 Park2 mutation carriers; M/F = 5/10; mean age = 40.2, SD = 14.7 years) and 22 age- and gender-matched healthy controls (HC; M/F = 10/12; mean age = 47.0, SD = 12.3 years) took part in the study (see for demographic, clinical and pharmacological characteristics). The diagnosis of clinically definite or probable PD was made according to the clinical …
…ristics at the preexcited segment in adult WPW syndrome patients and their implicated findings.
## Methods
For this prospective study, we enrolled 22 adult WPW syndrome patients (16 male, mean 45.4 ± 17.8 years) with echocardiographic findings of regional wall motion abnormality in our electrophysiology clinic. Of these patients, 14 underwent radiofrequency ablation before cardiac magnetic resonance i…